Benfotiamine is a fat-soluble B vitamin that has been used to treat diabetic complications. When I tried it, I had problems with my weight and my blood-sugar regulation that have not been reported in any of the studies I've seen.
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There appears to be a correlation between blood sugar levels and heart attack risk. Your blood sugar can be at the high end of "normal" and still increase your risk of health problems.
Prof JS Christiansen showed the following slide at the Annual Meeting of the EASD, Copenhagen, Sep 2006:
What this slide shows is the risk of heart attack based on your blood sugar levels 2 hours after eating 200 calories of glucose. This is not a lot of sugar, it is equivalent to the amount of carbohydrate in 18 oz of soda, or in a sandwich and a small bag of potato chips. And 96 is not particulary high blood sugar; this is well within the "normal" range if you have a blood test.
The death rate is dramatically higher, though, if your blood glucose if 96 or higher 2 hours after eating what is considered a "normal" or "small" amount of carbohydrate on a typical Western diet.
What this says to me is that managing your blood sugar is important, even when you have not developed full-fledged diabetes. As you age, your metabolism becomes less and less able to manage carbohydrate in an optimal manner, and you will accumulate damage at a higher and higher rate unless you actively work on it.